1.
Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19.
Aging (Albany NY)
; 12(24): 26263-26278, 2020 12 27.
Article
in English
| MEDLINE | ID: covidwho-1000742
ABSTRACT
Inflammaging constitutes the common factor for comorbidities predisposing to severe COVID-19. Inflammaging leads to T-cell senescence, and immunosenescence is linked to autoimmune manifestations in COVID-19. As in SLE, metabolic dysregulation occurs in T-cells. Targeting this T-cell dysfunction opens the field for new therapeutic strategies to prevent severe COVID-19. Immunometabolism-mediated approaches such as rapamycin, metformin and dimethyl fumarate, may optimize COVID-19 treatment of the elderly and patients at risk for severe disease.